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Plenhyage XL




What are polynucleotides?

Polynucleotides are natural, highly-purified DNA molecules usually extracted from the gonads of fish.

How do they work?

Cells have DNA, which is made of polynucleotides. When we inject more polynucleotides into aged and damaged skin cells, they help to regenerate tissue by stimulating fibroblasts – a type of cell that contributes to the formation of connective tissue. Essentially, we are healing skin from within. 

How are polynucleotides administered?

Polynucleotides are injected into aged and damaged and skin via specific techniques, depending on the product used. You can find out more about the protocols on our training course. 

How long do results last?

Patients can expect to see initial results after three weeks, which will last six to nine months.

What do the clinical studies say?

Results from multiple clinical studies for the polynucleotides we distribute – Plenhyage XL, PLINEST and NEWEST – all have fantastic outcomes. Get in touch for the specific details. 

Are there any side effects?

Side effects are minimal, depending on the injection technique used. As with any injection, patients can expect some slight redness and swelling following treatment. No serious adverse events have been reported. 

Can I use polynucleotides alongside other treatments?

Yes, absolutely. All of our polynucleotides can be offered as a stand-alone treatment or used in combination with any other procedure. 

We have seen excellent results alongside dermal filler, botulinum toxin, PRP and radiofrequency treatments.

How can I introduce polynucleotides to my patients?

You can be assured that when you invest in any of our products, you will benefit from thorough training and ongoing support that not only benefits patients, but boosts your business and expertise.

Click here to see our upcoming training dates and book your opportunity! 


In my practice, we always seek the most up-to-date and evidence-based treatments, and Polynucleotide product range distributed by DermaFocus definitely falls into this category. With these product, my patients have seen significant improvement in their skin quality, reducing wrinkles, and skin laxity.

At the same time, I’ve been able to add it as a valuable component in more complex treatments for severe scarring, hyperpigmentation, rosacea, and hair restoration; the combination of Polynucleotide with medical devices can lead to incredible results and reduce the downtime dramatically.

It’s exciting to have a new regenerative product on the market that works differently from the usual aesthetic tools. I’ve also been impressed by the level of support from the DermaFocus team which is always there when we need them.

Mr George ChristopoulosConsultant plastic surgeon