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An insight into the efficacy and safety of the technology used in the award-winning Plinest® polynucleotides

Polynucleotides are one of the most in-demand treatments in the UK right now. 

Grazia magazine recently reported that there’s been a dramatic 2446% increase in Google searches for ‘polynucleotides’ in the past few months alone, as patients are desperate to emulate the glowing skin of A-listers like Jennifer Anniston and Kim Kardashian, who have both openly talked about using polynucleotides.

Alongside this there has been a surge in companies launching different brands of polynucleotides, with hundreds more practitioners now advertising them to patients. 

Unfortunately, like in many areas of aesthetics, there will be products that don’t have much clinical research behind them, leaving patients with disappointing results. 

As the Home of Polynucleotides in the UK and one of the first regenerative aesthetic distribution and training companies in the UK, we outline why Polynucleotides HPT® (the manufacturing process and technology used in Plinest® and Newest®) is the brand you can trust. 

Well-sourced ingredients

The DNA fractions used in polynucleotides are extracted from fish gonads, with many brands using wild salmon which may have been exposed to pollution in the ocean. 

Instead, the DNA fractions used in Polynucleotides HPT® come from trout that have been bred in fresh waters, where every stage of production is controlled. After the DNA has been extracted, fish are used for food supply so there is no waste.

Stringent production process

Polynucleotides HPT® is created in the Mastelli pharmaceutical lab, which has all relevant regulatory certificates, and adheres to the highest clinical standards necessary. Mastelli has more than 70 years’ polynucleotides research and development experience, so you can trust they know what they’re doing when it comes to manufacturing this technology. 
The DNA fractions go through a stringent purification and sterilisation process, which ensures no proteins or lipids (which could cause an allergic reaction) get through to the final product. Only the most powerful and safe ingredients are used!

Extensive clinical research

Polynucleotides HPT® has been tested and analysed on multiple patients for numerous concerns.

When injected intradermally, Polynucleotides HPT® promotes a trophic and stimulating action on existing fibroblasts and has been found to increase collagen synthesis and the viability/number of fibroblasts. It also promotes hydration and scavenging.

A peer-reviewed consensus report highlights that the Polynucleotides HPT® used in Plinest® and Newest® can successfully treat wrinkles, scars, skin laxity, pigmentation, dryness and acne. It has been found to be an excellent skin primer, boosting the results of laser, radiofrequency, fillers, chemical peels, microneedling and surgery.  Polynucleotides HPT® is also used in Plinest® Hair and is clinically proven to boost hair count and quality. 
The products that use Polynucleotides HPT® are classified as Class III CE-marked 0373 medical devices.

Reliable safety data

No complications from Polynucleotides HPT® have been reported, while side effects are acknowledged as minimal. Research highlights how they appear to be ‘no more severe than mild and transient discomfort, irritation or pain at the injection site’.

When you attend a DermaFocus training course for Polynucleotides HPT® products, you’ll be taught how to avoid and manage complications with a key focus on aseptic technique and appropriate patient selection. 


So, if this has helped reassure you that Polynucleotides HPT® is THE most reliable regenerative technology, then book your training today!