The Clinical Case for NewGyn®: Regenerative Intimate Aesthetics Backed by Evidence 

In the evolving field of regenerative aesthetics, intimate health is emerging from the shadows of clinical conversation. While itching, dryness, and laxity in the vulvo-vaginal area are among the most under-reported symptoms in aesthetic consultations, they are neither rare nor trivial. 

Now, clinical research is making it clear: regenerative treatments like NewGyn® offer a safe, evidence-based solution to a highly prevalent – and underserved – patient need. 

Why vulvo-vaginal ageing demands attention 

Vulvo-vaginal atrophy (VVA), also described as Genitourinary Syndrome of Menopause (GSM), affects nearly half of postmenopausal women within five years of menopause. 

Despite this, approximately 50% of women never receive treatment, and those who do often rely on temporary over-the-counter solutions like lubricants or moisturisers. This leaves a significant care gap – a gap that NewGyn® is poised to fill. 

The research: biorevitalisation with Polynucleotides HPT® and HA 

A 2019 prospective cohort study by Palmieri and Raichi explored the use of Polynucleotides HPT® and hyaluronic acid in a sequential injectable protocol for postmenopausal labial tissue regeneration. 

Study methods: 

1. Participants: 19 postmenopausal women (natural or surgical menopause), aged 50-65, all with confirmed vulvovaginal atrophy and symptoms for at least one year. 
2. Treatment protocol: 
3. 3 ‘priming’ sessions using 40mg/2ml Polynucleotides HPT® 
4. 2 ‘consolidation’ sessions with 40mg/2ml of hyaluronic acid 
5. Treatments were spaced 2-3 weeks apart, with topical lidocaine used for comfort. 
6. Evaluation: Symptoms were assessed using a visual analogue scale (VAS) at baseline and at multiple time points up to 90 days. 

Key results: rapid, meaningful symptom relief 

By day 90, symptom scores dropped by 59–76% across all major indicators: 

Symptom	Improvement vs. Baseline
Itching	–76.3%
Soreness/Tingling	–70.1%
Vaginal Dryness	–59.1%
Dyspareunia (Pain with sex)	–59.4%
Irritation	–54.0%

Notably, most patients reported significant symptom relief after just two sessions of Polynucleotides HPT®, suggesting rapid onset of action. Improvements continued and deepened after HA consolidation treatments. 

Mechanism of action: why the combination works 

The clinical rationale for the Polynucleotides HPT® + HA protocol is rooted in their synergistic regenerative effects: 

1. Polynucleotides HPT activate fibroblast function, enhance collagen/elastin production, and improve extracellular matrix quality. The authors also suggest that the rapid improvement in soreness and tingling may point to a potential neuroprotective or neurotrophic effect of polynucleotides – though this remains speculative and warrants further research. 
2. Hyaluronic acid delivers deep hydration, supports fibroblast trophism, and helps restore mucosal turgor and elasticity. 

This combined action mirrors protocols already well-established in facial biorevitalisation – now proven effective in vulvo-vaginal tissues as well. 

Safety, compliance and satisfaction 

1. No adverse events were reported during the study period. 
2. 100% of participants completed the protocol. 
3. All women expressed satisfaction with both symptom relief and aesthetic outcomes. 

The study’s authors concluded that “both the documented bio-reactivating properties of polynucleotides in the skin and their synergy with hyaluronic acid might also be expressed in postmenopausal vulvovaginal tissues” – an assertion supported by rapid, consistent improvements and high tolerability. 

Bringing evidence-based intimate aesthetics into your practice 

With its well-documented safety and efficacy, NewGyn® offers aesthetic practitioners a powerful new tool for addressing intimate ageing – without the risks or controversies of hormone-based therapies. 

For patients seeking non-hormonal, clinically validated relief from vulvovaginal discomfort, NewGyn® delivers measurable results in a matter of weeks. 

Invest in certified training 

DermaFocus provides Masterclasses covering: 

1. Patient selection and assessment 
2. Injection techniques for intimate areas 
3. Real-world case data and protocol customisation 

Whether you’re expanding your regenerative offerings or seeking to support your perimenopausal and postmenopausal patients more holistically, now is the time to integrate intimate aesthetics into your care model. 

Book your training with DermaFocus today.