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What is mesotherapy?

Originally developed to treat vascular and lymphatic disorders, mesotherapy has more recently been used for skin rejuvenation. The method consists in multiple and micro-dosed injections of bioactive products into the skin to increase its hydration and reconstruct an optimal physiological environment for the fibroblasts. It is aimed in particular at enhancing cell activity and synthesis of collagen, elastin and hyaluronic acid (HA).

HA plays an important role in the hydration of the extracellular space due to its ability to attract water molecules and it is thought to create the physiological conditions in the extracellular matrix for proliferation, migration and organisation of dermal cells. 

Clinical experience of skin rejuvenation by HA-based mesotherapy suggests this technique is safe and it can improve skin hydration, firmness and viscoelastic properties and some results on thickness.

There are some studies that have shown a sustained increase in dermis thickness 1 and 3 months after the last mesotherapy session.

Dermis thickening may be explained by the fact that the mechanical stimulation of microinjections induce dermis micro-inflammation with vasodilatation persisting 1 month after the last injection session and in some clients this could still be seen up to 3 months later.

The newly formed fibres may be more compliant and their greater number and entanglement may reinforce the collagen and elastin network, which is embedded in a proteoglycan and glycosaminoglycan gel to form the dermis. 

What is Microneedling (or Percutaneous Collagen Induction therapy)?

This is mini invasive therapeutic method for the treatment of skin alterations of different aetiology.

Microneedling is micron-sized and breaches the outermost layer of the skin – the stratum corneum – creating transient, aqueous pores in the skin and facilitating the transport of therapeutic molecules into the epidermis. This technique is also used as a way to deliver cosmeceutic molecules across the skin, in addition to their use in combinatorial treatments.

Scars can also be treated with microneedling as the technique can activate the healing cascade and growth factors, which activate cell proliferation in the wound, increased synthesis and the deposit of collagen and elastin complex with successive transformation of collagen III to collagen I, to neo-angiogenesis and thus to accelerated scar remodelling.
Both techniques, Mesotherapy and Microneedling were used and still are to deliver therapeutic molecules and now, after years of clinical studies we know we can use those effective and safe techniques to deliver aesthetic molecules as HA and peptides.

Tips and techniques for Mesotherapy and Microneedling in your business

  • Create a bespoke journey for your client by alternating Mesotherapy and Microneedling- this is the best way to stimulate growth factors and collagen.
  • The most common formulation of Mesotherapy for facial skin rejuvenation includes injections of a multivitamin solution and Hyaluronic Acid.
  • Hyaluronic Acid injections induce the synthesis of dermis components such as elastin and collagen which may contribute to dermis thickness increase and be responsible for the remanence.
  • Hyaluronic Acid microinjections induce a significant and sustainable improvement in complexion radiance.

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