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Polynucleotides (PDRN) modulates inflammation and there is lots of evidence that supports it.

The ability of polynucleotides to control inflammation as observed in several in vitro studies, simplified models of the main biological mechanism mediating its anti-inflammatory effect and confirmed in vivo and clinical models.

Skin aging and most age-related issues are associated with a low-grade chronic inflammation.

Polynucleotides activates adenosine A2A receptors and it immediately promotes a mechanism of defence against the inflammatory damage.

Rosacea is a chronic inflammatory skin condition that mainly affects the face causing blushing or flushing and visible blood vessels.

Rosacea affects only skin on your nose, cheeks, and forehead. Typical symptom is small, red, pus-filled bumps in severe cases on the skin that are present during flare-ups. Because causes of rosacea are difficult to address, treating it is very challenging.   

Plenhyage XL is the solution for this kind of skin. Just after 2 treatments you can have positive results.